Flight Tocumen International Airport departs from Panama City Tocumen International Airport at 21:22 and arrives at Asuncion Silvio Pettirossi International Airport at 05:28.
The flighttime is about 3h 06m. The distance travelled ("as the bird flies"): 2710 Km. So the average speed is roughly 874 Km.
There is an 5 hour time difference between Panama City and Asuncion