Flight Sheremetyevo International Airport departs from Moscow Sheremetyevo International Airport at 20:45 and arrives at Tashkent International Airport at 02:45.
The flighttime is about 4h 00m. The distance travelled ("as the bird flies"): 3653 Km. So the average speed is roughly 913 Km.
There is an 2 hour time difference between Moscow and Tashkent