Please be aware that Rome has multiple airports and that these results are only for Leonardo da Vinci–Fiumicino Airport.
The best month to arrive at Rome is February and the most expensive month to fly is June. (Average prices, based on 211 datapoints.)
The best day to arrive at Rome is Wednesday and it would be best to avoid Saturday, as prices are on average 99.88% higher than on Wednesday. (Average prices, based on 595 datapoints.)
The cheapest airline flying to Rome is Vueling. They are 83% cheaper than Lufthansa. (Average prices, based on 298 datapoints.)
At Rome the most flights depart around 11:00. (Hourly flights, based on 366 datapoints.)
From Rome it is on average the cheapest to fly to Brussels and to Madrid. (Average prices, based on 432 datapoints.)