Flight Guarulhos International Airport departs from Sao Paulo Guarulhos International Airport at 21:50 and arrives at Houston George Bush Intercontinental Airport at 05:40.
The flighttime is about 9h 50m. The distance travelled ("as the bird flies"): 5211 Km. So the average speed is roughly 530 Km.
There is an 2 hour time difference between Sao Paulo and Houston