Flight Guarulhos International Airport departs from Sao Paulo Guarulhos International Airport at 22:20 and arrives at Chicago O'Hare International Airport at 06:45.
The flighttime is about 10h 25m. The distance travelled ("as the bird flies"): 4747 Km. So the average speed is roughly 456 Km.
There is an 2 hour time difference between Sao Paulo and Chicago