Flight Tocumen International Airport departs from Panama City Tocumen International Airport at 16:17 and arrives at Santa Cruz Viru Viru International Airport at 22:17.
The flighttime is about 1h 00m. The distance travelled ("as the bird flies"): 1999 Km. So the average speed is roughly 1999 Km.
There is an 5 hour time difference between Panama City and Santa Cruz