Flight Tocumen International Airport departs from Panama City Tocumen International Airport at 21:43 and arrives at Santa Cruz Viru Viru International Airport at 03:38.
The flighttime is about 0h 55m. The distance travelled ("as the bird flies"): 1999 Km. So the average speed is roughly 2181 Km.
There is an 5 hour time difference between Panama City and Santa Cruz