Flight Jinnah International Airport departs from Karachi Jinnah International Airport at 05:50 and arrives at Istanbul Istanbul Atatürk Airport at 09:45.
The flighttime is about 6h 55m. The distance travelled ("as the bird flies"): 4398 Km. So the average speed is roughly 636 Km.
There is an 3 hour time difference between Karachi and Istanbul
