Flight O'Hare International Airport departs from Chicago O'Hare International Airport at 21:20 and arrives at Sao Paulo Guarulhos International Airport at 09:30.
The flighttime is about 10h 10m. The distance travelled ("as the bird flies"): 4747 Km. So the average speed is roughly 467 Km.
There is an 2 hour time difference between Chicago and Sao Paulo