Flight Guarulhos International Airport departs from Sao Paulo Guarulhos International Airport at 15:45 and arrives at Rome Leonardo da Vinci–Fiumicino Airport at 07:10.
The flighttime is about 12h 25m. The distance travelled ("as the bird flies"): 9189 Km. So the average speed is roughly 740 Km.
There is an 3 hour time difference between Sao Paulo and Rome