Flight Guarulhos International Airport departs from Sao Paulo Guarulhos International Airport at 04:10 and arrives at Istanbul Istanbul Atatürk Airport at 22:35.
The flighttime is about 12h 25m. The distance travelled ("as the bird flies"): 10574 Km. So the average speed is roughly 852 Km.
There is an 6 hour time difference between Sao Paulo and Istanbul
