The best day to arrive at Prague is Tuesday and it would be best to avoid Friday, as prices are on average 70.4% higher than on Tuesday. (Average prices, based on 227 datapoints.)
From Prague it is on average the cheapest to fly to Brussels and to Brussels. (Average prices, based on 153 datapoints.)
From Prague most of the flights depart to Amsterdam, second best connected from Prague is London. (Daily flights, based on 54 datapoints.)