Flight Leonardo da Vinci–Fiumicino Airport departs from Rome Leonardo da Vinci–Fiumicino Airport at 12:35 and arrives at Istanbul Sabiha Gökcen International Airport at 17:05.
The flighttime is about 3h 30m. The distance travelled ("as the bird flies"): 1899 Km. So the average speed is roughly 543 Km.
There is an 1 hour time difference between Rome and Istanbul