Flight Leonardo da Vinci–Fiumicino Airport departs from Rome Leonardo da Vinci–Fiumicino Airport at 14:05 and arrives at Istanbul Sabiha Gökcen International Airport at 18:45.
The flighttime is about 3h 40m. The distance travelled ("as the bird flies"): 1899 Km. So the average speed is roughly 518 Km.
There is an 1 hour time difference between Rome and Istanbul