Flight Heathrow Airport departs from London Heathrow Airport at 21:15 and arrives at Sao Paulo Guarulhos International Airport at 06:00.
The flighttime is about 12h 45m. The distance travelled ("as the bird flies"): 8821 Km. So the average speed is roughly 692 Km.
There is an 4 hour time difference between London and Sao Paulo