Flight Tocumen International Airport departs from Panama City Tocumen International Airport at 18:25 and arrives at Guayaquil Simon Bolivar International Airport at 20:42.
The flighttime is about 21h 17m. The distance travelled ("as the bird flies"): 231 Km. So the average speed is roughly 11 Km.
There is an 5 hour time difference between Panama City and Guayaquil