Please be aware that Istanbul has multiple airports and that these results are for all airports serving the city.
The best month to fly between Istanbul and Amsterdam is February and the most expensive month to fly is August. (Average prices, based on 717 datapoints.)
The best day to arrive at Istanbul is Wednesday and it would be best to avoid Saturday, as prices are on average 89% higher than on Wednesday. (Average prices, based on 792 datapoints.)
The cheapest airline flying from Istanbul to Amsterdam is Pegasus Airlines. They are 45% cheaper than KLM. (Average prices, based on 728 datapoints.)
The best time to fly is at around 9. (Average prices, based on 1448 datapoints.)