Please be aware that Rome has multiple airports and that these results are for all airports serving the city.
The best month to arrive at Rome is January and the most expensive month to fly is April. (Average prices, based on 808 datapoints.)
The best day to arrive at Rome is Wednesday and it would be best to avoid Saturday, as prices are on average 74.83% higher than on Wednesday. (Average prices, based on 693 datapoints.)
The cheapest airline flying to Rome is Ryanair. They are 80% cheaper than Air France. (Average prices, based on 920 datapoints.)
At Rome the most flights depart around 11:00. (Hourly flights, based on 975 datapoints.)
From Rome it is on average the cheapest to fly to Madrid and to Brussels. (Average prices, based on 473 datapoints.)