Please be aware that Rome has multiple airports and that these results are for all airports serving the city.
The best month to arrive at Rome is May and the most expensive month to fly is April. (Average prices, based on 234 datapoints.)
The best day to arrive at Rome is Wednesday and it would be best to avoid Saturday, as prices are on average 87.05% higher than on Wednesday. (Average prices, based on 689 datapoints.)
The cheapest airline flying to Rome is Vueling. They are 83% cheaper than Lufthansa. (Average prices, based on 321 datapoints.)
At Rome the most flights depart around 11:00. (Hourly flights, based on 391 datapoints.)
From Rome it is on average the cheapest to fly to Brussels and to Madrid. (Average prices, based on 432 datapoints.)